Nanomedicine – September 2011

A Elsaesser, CA Barnes, G McKerr, A Salvati… – …, 2011 – Future Medicine
Stereology software (Mercator, Explora Nova) was used to overlay sections with unbiased counting frames (Figure 6), each with an area per frame, a/f, of 2500 µm 2 . Cell transects were counted according to an unbiased counting rule [28] and cell transect density was

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Intuitive Stereology

“We have been using Mercator during the last 5 years and the software suits our needs perfectly. Our main research line consists of the quantification of several structures (neurons, vessels and astrocytes) separating cortical layers, and Mercator allows us to do it in a easy and fast way, using the most often used stereological procedures (optical disector and Cavalieri method). The stereological procedures are integrated in a very intuitive way, making a fast learning curve, this is a key point in our work. The easier the training procedure, the faster we start getting results from junior researchers. Another feature of Mercator is that it is very easy to fit to specific individual requirements, as it is a modular open system and easy to configure to available equipment. Last but not least, the use of Mercator allows us to fulfill the requirements of referees in high impact journals, that only accept quantitative results when unbiased procedures have been used.”

Prof. Enrike G. Argandoria
Faculty of Medicine
University of the Basque Country – Spain

Parkinson’s Disease – April 2011

L Faustine, T Reynald – Parkinson’s Disease, 2011 – hindawi.com
and random systematic sampling [27]. The Mercator stereology analysis software (Explora Nova, La Rochelle, France) was utilized to perform unbiased stereological counts of BrdU positive cell. For the unbiased quantification

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Stereology Week 2011

Presented by Vyvyan HOWARD, Gesa STAATS de YANES and Olivier LEJEUNE

was held 22 – 25 March 2011 at Victor Segalen Bordeaux University, Place de la Victoire, Bordeaux, France

click here to download the pdf version of the Course Booklet.

 

Stereology Course 2011

Stereology Course 2011

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Journal of Microscopy – July 2010

MG Reed, CV Howard… – Journal of Microscopy, 2010 – Wiley Online Library
This approach can be carried out either manually or with an interactive software package (Explora Nova, 2007). The French software company Explora Nova has realized an interactive software that implements the One-Stop Stereology approach described in this paper.
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International Journal of Neuropsychopharmacology – April 2010

C Miguelez, L Grandoso… – Int. J. …, 2010 – Cambridge Univ Press
intact side (100%) with the background associated with the cortex being set as 0%. Stereological cell counting was performed in regularly spaced sections along the LC by the optical dis- sector method using the Mercator image analysis system (Explora Nova, France). Drugs
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Stereology

Featured

Stereology is the estimation of geometrical quantities. Sometimes stereology is described as a method to estimate 3D quantities from 2D information, but this is not always the case.

The term stereology was coined in 1962 at the first meeting of the International Stereological Society.
Stereological methods concern the estimation of quantitative properties of spatial materials from lower-dimensional information such as that generated by a cross-section of  the material.
- the first order stereology estimates quantities as a number, length, surface or volume,
- the second order stereology estimates the spatial organisation of objects.

With Mercator and its stereological module, the microscope becomes a user-friendly tool to obtain these measurements. All these tools are developed and verified in collaboration with Prof C.V.Howard and his team, from The University of Ulster.
The Stereology module gives you a set of convenient, unbiased and efficient tools and methods for quantification of multi-dimensional characteristics of organs, tissues and cells. With the correct sampling strategy, and depending on the orientation of the tissue to be analyzed, this add-on gives you access to a large palette of stereological tools.

See what Prof. C.V. Howard has to say about Mercator

See also http://www.unbiased-stereology.com to order the book:

“Unbiased Stereology, 2nd Edition”.

European Journal of Neuroscience – December 2009

M Martinez, JM Brezun… – European Journal …, 2009 – Wiley Online Library
1D–F). Sections were digitally imaged and analyzed for an unbiased stereological estimation of tissue volume loss at 1 and 2 months after the lesion by the Cavalieri method using Mercator software (Explora Nova, France).
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