BONE is a complete quantification system that can be adapted to any microscope. This sytem is specially designed to help the biologist explore and analyze bone slides according to international bone histomorphometry standards (Bone Histomorphometry : Standardization of Nomenclature, Symbols and Units. Parfitt et al Journal of Bone and Mineral Research 1987, Vol 2, n?6, 595-610, Mary Ann Liebert, Inc., Publishers).

The calculated parameters are as follows :

Structural analysis on entire biopsy specimen

• Corticales - Ct.Ar, Ca.Ar, Ca.N - Ct.Por, Ct.Th
• Spongy tissue - TV, BV, BS - S, TBV, Tb.Th, Tb.N, Tb.Sp, TBPf -
• Marrow Star Volume -
• Fractal Dimension
• Skeleton - TSL, TV, Nd.N, Tm.N, O.N, C.N - Nd.N / Tm.N, etc. - Nd to Tm.N, Nd to Tm.Le (m), etc.
  
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Complementary study

• Osteoid - OV, OS, O.Th - OS/BS, OV/BV
• Resorption - EV, ES, E.De, Max E.De - ES/BS, EV/BV
• Osteoclast - Oc.N Osteoblast - Ob.N

Kinetic study of mineral metabolism

• SL S, DL S - SL S/BS, DL S /BS, MAR, MS/BS, BFR

Software validation by M J.P. ROUX - INSERM Unit 403 Lyon - France -Director Pr. P.D. DELMAS